DTD1

Across TCGA patient cohorts, DTD1 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DTD1-associated genes across cancer lineages are VHL, eIF4E, and Ku80. Each is linked with DTD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DTD1-to-partner and partner-to-DTD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by DTD1-low versus DTD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DTD1→partner) and Y-score (partner→DTD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-1.735	-3.700	<.001	.001	3	2
UCEC	eIF4E →	+0.208	+3.169	.034	.019	3	1
UCEC	Ku80 →	+0.220	+3.013	.045	.018	3	1
UCEC	p62 Lck ligand →	+0.411	+3.700	.006	.001	3	1
UCEC	Tuberin →	+0.378	+2.331	.002	.019	3	1
UCEC	Chk1 →	-0.152	-2.999	.049	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

VHL by DTD1 expression — UCEC

Explore this box plot interactively →