DTD1

Across TCGA cell cohorts, DTD1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,829 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DTD1-associated GO terms across cancer lineages are Protein histidyl modification to diphthamide, Peptidyl-histidine modification, and Positive regulation of protein localization to endoplasmic reticulum. Each is linked with DTD1 in more than 6 cancer types. Because this analysis shows association rather than direction, both DTD1-to-partner and partner-to-DTD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein histidyl modification to diphthamide grouped by DTD1-low versus DTD1-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DTD1→partner) and Y-score (partner→DTD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Protein histidyl modification to diphthamide →	+0.095	+0.993	.004	.005	3	7
URINARY_TRACT	Peptidyl-histidine modification →	+0.095	+0.993	.004	.005	3	7
SOFT_TISSUE	Positive regulation of protein localization to endoplasmic reticulum →	+0.094	+0.547	.004	.007	3	7
LIVER	Positive regulation of postsynaptic membrane organization →	+0.141	+1.090	.002	.002	3	7
LIVER	Positive regulation of AMPA glutamate receptor clustering →	+0.141	+1.090	.002	.002	3	7
UPPER_AERODIGESTIVE_TRACT	Positive regulation of glutamate secretion, neurotransmission →	+0.183	+0.554	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,829 associations by consensus.

Protein histidyl modification to diphthamide by DTD1 expression — URINARY_TRACT

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