DSTN

Across TCGA patient cohorts, DSTN mutation is significantly associated with the RNA expression of many other genes, with 550 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DSTN-associated genes across cancer lineages are RPS29P32, IGHV1OR21-1, and RNA5SP405. Each is linked with DSTN in more than 1 cancer types. Because this analysis shows association rather than direction, both DSTN-to-partner and partner-to-DSTN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS29P32 grouped by DSTN-low versus DSTN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSTN→partner) and Y-score (partner→DSTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPS29P32 →	+0.447	+2.751	<.001	.002	3	1
UCEC	IGHV1OR21-1 →	+0.642	+2.537	.004	.005	3	1
LUAD	RNA5SP405 →	+0.308	+7.930	<.001	.008	3	1
LUAD	SNORD115-3 →	+0.401	+7.930	<.001	.008	3	1
LUAD	RNA5-8SP7 →	+0.681	+7.930	<.001	.008	3	1
LUAD	MIR1185-2 →	+0.387	+7.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 550 associations by consensus.

RPS29P32 by DSTN expression — UCEC

Explore this box plot interactively →