DSTN

Across TCGA patient cohorts, DSTN mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DSTN-associated genes across cancer lineages are EGFR_pY1068, ERK2, and Fibronectin. Each is linked with DSTN in more than 1 cancer types. Because this analysis shows association rather than direction, both DSTN-to-partner and partner-to-DSTN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by DSTN-low versus DSTN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSTN→partner) and Y-score (partner→DSTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.429	-3.459	<.001	.005	3	1
UCEC	ERK2 →	+0.229	+2.321	.018	.035	3	1
UCEC	Fibronectin →	-0.330	-2.990	.046	.036	3	1
UCEC	Gab2 →	+0.363	+2.321	.042	.035	3	1
UCEC	Ku80 →	+0.313	+3.472	.008	.002	3	1
UCEC	Rab25 →	-0.503	-3.459	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

EGFR_pY1068 by DSTN expression — UCEC

Explore this box plot interactively →