DST-AS1

Across TCGA pan-cancer cohorts, DST-AS1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated DST-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher DST-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DST-AS1 expression acts as an unfavorable survival marker, although some lineages such as COAD and KIRP show a favorable association.

KIRC, MESO, and HNSC are the cancer types where DST-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.563	0.693	<.001	120	view →
MESO	OS	Median	All	0.281	0.485	.002	74	view →
HNSC	DFS	Quartile	All	0.529	0.721	.002	41	view →
COAD	DFS	Tertile	III,IV	0.559	0.292	.007	34	view →
SKCM	OS	Tertile	III,IV	0.162	0.543	.001	30	view →
KIRP	DFS	Median	II,III,IV	0.873	0.323	.004	24	view →
LAML	DFS	Median	All	0.550	0.247	.002	16	view →
THYM	DFS	Quartile	III,IV	0.273	0.791	.004	16	view →
ESCA	DFS	Quartile	All	0.195	0.851	.007	12	view →
THCA	DFS	Quartile	All	0.945	0.677	.017	11	view →
LIHC	DFS	Quartile	All	0.202	0.320	.005	11	view →
UVM	DFS	Median	II,III,IV	0.874	0.607	.028	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

DST-AS1–KIRC (OS)

Open the KIRC breakdown →