DSPP

Across TCGA patient cohorts, DSPP RNA expression is significantly associated with the protein abundance of many other proteins, with 18,040 significant associations in total. GBM shows the largest number of these associations.

The most reproducible DSPP-associated proteins across cancer lineages are SPP1_S234, STON2_S227, and ANK2_S1461. Each is linked with DSPP in more than 4 cancer types. Because this analysis shows association rather than direction, both DSPP-to-partner and partner-to-DSPP results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DSPP versus SPP1_S234 in PDAC, with a Pearson correlation of 0.52.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DSPP→partner) and Y-score (partner→DSPP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SPP1_S234 →	+1.001	+0.674	<.001	<.001	3	5
CCRCC	STON2_S227 →	-0.499	-0.400	.001	.008	3	4
GBM	ANK2_S1461 →	-0.558	-0.890	<.001	<.001	3	4
LSCC	JAK1 →	-0.224	-0.655	<.001	<.001	3	4
LSCC	MAP4K1 →	-0.343	-0.517	<.001	.007	3	4
GBM	CDKN1B →	-0.428	-0.763	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,040 associations by consensus.

DSPP vs SPP1_S234 — PDAC

Explore this scatter interactively →