DSPP

Across TCGA patient cohorts, DSPP mutation is significantly associated with the RNA expression of many other genes, with 3,618 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DSPP-associated genes across cancer lineages are PSMA5P1, RNA5SP413, and RBBP8. Each is linked with DSPP in more than 2 cancer types. Because this analysis shows association rather than direction, both DSPP-to-partner and partner-to-DSPP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMA5P1 grouped by DSPP-low versus DSPP-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSPP→partner) and Y-score (partner→DSPP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PSMA5P1 →	+0.207	+4.652	<.001	.003	3	3
LUSC	RNA5SP413 →	+0.744	+3.858	<.001	.002	3	3
UCEC	RBBP8 →	+0.593	+2.212	<.001	<.001	3	3
UCEC	KCTD9 →	+0.582	+1.519	<.001	<.001	3	3
UCEC	CACYBP →	+0.337	+1.373	.009	.001	3	3
UCEC	KIF18A →	+0.471	+1.233	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,618 associations by consensus.

PSMA5P1 by DSPP expression — BRCA

Explore this box plot interactively →