DSPP

Across TCGA patient cohorts, DSPP mutation is significantly associated with the total protein of many other genes, with 83 significant associations in total. COAD shows the largest number of these associations.

The most reproducible DSPP-associated genes across cancer lineages are C-Raf, Rad50, and ASNS. Each is linked with DSPP in more than 2 cancer types. Because this analysis shows association rather than direction, both DSPP-to-partner and partner-to-DSPP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by DSPP-low versus DSPP-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSPP→partner) and Y-score (partner→DSPP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	C-Raf →	+0.183	+2.814	.044	.037	3	3
UCEC	Rad50 →	-0.181	-1.273	.007	.007	3	3
UCEC	ASNS →	+0.304	+1.289	.002	.021	3	3
UCEC	ATM →	-0.481	-1.447	<.001	.002	3	3
UCEC	Cyclin-E2 →	+0.115	+0.947	.015	.047	3	3
SKCM	c-Kit →	-0.810	-3.087	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 83 associations by consensus.

C-Raf by DSPP expression — BRCA

Explore this box plot interactively →