DSPP

Across TCGA cell cohorts, DSPP mutation is significantly associated with the RNA expression of many other genes, with 41 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DSPP-associated genes across cancer lineages are IL17A, NEUROD4, and PRY2. Each is linked with DSPP in more than 1 cancer types. Because this analysis shows association rather than direction, both DSPP-to-partner and partner-to-DSPP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL17A grouped by DSPP-low versus DSPP-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSPP→partner) and Y-score (partner→DSPP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	IL17A →	+0.052	+5.169	<.001	.005	3	2
URINARY_TRACT	NEUROD4 →	+0.196	+5.087	<.001	.004	3	1
URINARY_TRACT	PRY2 →	+0.060	+5.087	<.001	.004	3	1
SOFT_TISSUE	TNP1 →	+1.140	+5.954	<.001	<.001	3	1
SOFT_TISSUE	RLN3 →	+0.030	+4.369	<.001	.008	3	1
LUNG_SCLC	OR4C3 →	+0.055	+4.643	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

IL17A by DSPP expression — BREAST

Explore this box plot interactively →