DSP

Across TCGA pan-cancer cohorts, DSP mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated DSP data layer compared with 22 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher DSP mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DSP expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

PDAC, LSCC, and LUAD are the cancer types where DSP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	II,III,IV	0.624	0.297	.006	29	view →
LSCC	DFS	Tertile	II,III,IV	0.907	0.547	.006	27	view →
LUAD	DFS	Median	All	0.476	0.790	<.001	24	view →
HNSC	DFS	Median	II,III,IV	0.986	0.885	.005	23	view →
UCEC	DFS	Quartile	II,III,IV	1.000	0.309	.003	14	view →
COAD	DFS	Tertile	All	1.000	0.925	.048	6	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

DSP–PDAC (DFS)

Open the PDAC breakdown →