DSP

Across TCGA patient cohorts, DSP mutation is significantly associated with the total protein of many other genes, with 96 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DSP-associated genes across cancer lineages are ATM, ASNS, and 4E-BP1. Each is linked with DSP in more than 5 cancer types. Because this analysis shows association rather than direction, both DSP-to-partner and partner-to-DSP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by DSP-low versus DSP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSP→partner) and Y-score (partner→DSP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.478	-1.450	<.001	<.001	3	6
COAD	ASNS →	+0.492	+2.700	<.001	.005	3	5
UCEC	4E-BP1 →	+0.333	+1.725	<.001	<.001	3	5
COAD	Caspase-7-cleavedD198 →	+1.249	+3.476	<.001	.002	3	3
UCEC	Cyclin-B1 →	+0.567	+1.450	<.001	<.001	3	3
UCEC	eEF2 →	+0.217	+1.514	.013	.012	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 96 associations by consensus.

ATM by DSP expression — UCEC

Explore this box plot interactively →