DSP

Across TCGA cell cohorts, DSP RNA expression is significantly associated with the go_rna of many other GO terms, with 3,686 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible DSP-associated GO terms across cancer lineages are Desmosome maintenance, Cardiac muscle cell-cardiac muscle cell adhesion, and Bundle of His cell to Purkinje myocyte communication. Each is linked with DSP in more than 17 cancer types. Because this analysis shows association rather than direction, both DSP-to-partner and partner-to-DSP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Desmosome maintenance grouped by DSP-low versus DSP-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DSP→partner) and Y-score (partner→DSP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Desmosome maintenance →	+1.932	+4.833	<.001	<.001	3	18
SKIN	Cardiac muscle cell-cardiac muscle cell adhesion →	+0.739	+2.032	<.001	<.001	3	14
URINARY_TRACT	Bundle of His cell to Purkinje myocyte communication →	+0.575	+3.668	.008	<.001	3	13
SKIN	Bundle of His cell-Purkinje myocyte adhesion involved in cell communication →	+0.781	+1.667	<.001	<.001	3	13
STOMACH	Desmosome organization →	+0.424	+2.524	<.001	<.001	3	12
SKIN	Desmosome assembly →	+0.836	+2.271	.004	.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,686 associations by consensus.

Desmosome maintenance by DSP expression — URINARY_TRACT

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