DSP

Across TCGA cell cohorts, DSP mutation is significantly associated with the RNA expression of many other genes, with 978 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DSP-associated genes across cancer lineages are ZBTB39, PDP2, and FOXD2. Each is linked with DSP in more than 2 cancer types. Because this analysis shows association rather than direction, both DSP-to-partner and partner-to-DSP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZBTB39 grouped by DSP-low versus DSP-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSP→partner) and Y-score (partner→DSP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ZBTB39 →	+0.617	+3.351	.004	.003	3	3
BLOOD_Leukemia	PDP2 →	+0.797	+3.351	.002	.003	3	3
BLOOD_Leukemia	FOXD2 →	+0.578	+3.351	.001	.003	3	3
BLOOD_Leukemia	ZKSCAN5 →	+0.550	+3.367	.001	.002	3	3
BLOOD_Lymphoma	FCN2 →	+0.030	+3.129	<.001	.002	3	2
BLOOD_Lymphoma	PNLIPRP3 →	+0.434	+2.878	.002	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 978 associations by consensus.

ZBTB39 by DSP expression — BLOOD_Leukemia

Explore this box plot interactively →