DSG4

Across TCGA pan-cancer cohorts, DSG4 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated DSG4 data layer compared with 17 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher DSG4 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated DSG4 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

ACC, HNSC, and KIRP are the cancer types where DSG4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.010	0.667	<.001	45	view →
HNSC	DFS	Median	All	0.157	0.628	.014	21	view →
KIRP	DFS	Median	II,III,IV	0.037	0.783	<.001	17	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
COAD	OS	Median	III,IV	0.159	0.692	.021	6	view →
LUAD	DFS	Median	III,IV	0.524	0.398	.015	4	view →
STAD	OS	Median	All	0.325	0.586	.032	3	view →
SKCM	DFS	Median	III,IV	0.285	0.555	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

DSG4–ACC (DFS)

Open the ACC breakdown →