DSG4

Across TCGA patient cohorts, DSG4 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,908 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible DSG4-associated GO terms across cancer lineages are Regulation of keratinocyte proliferation, Peptidyl-threonine modification, and Autophagosome organization. Each is linked with DSG4 in more than 12 cancer types. Because this analysis shows association rather than direction, both DSG4-to-partner and partner-to-DSG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of keratinocyte proliferation grouped by DSG4-low versus DSG4-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DSG4→partner) and Y-score (partner→DSG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Regulation of keratinocyte proliferation →	+0.046	+0.300	<.001	<.001	3	12
STAD	Peptidyl-threonine modification →	+0.056	+0.271	<.001	.002	3	12
STAD	Autophagosome organization →	+0.044	+0.156	<.001	.004	3	12
TGCT	Post-Golgi vesicle-mediated transport →	+0.033	+0.202	<.001	<.001	3	12
STAD	Cardiac muscle cell-cardiac muscle cell adhesion →	+0.106	+0.235	<.001	<.001	3	12
UCEC	Temperature homeostasis →	+0.015	+0.225	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,908 associations by consensus.

Regulation of keratinocyte proliferation by DSG4 expression — ESCA

Explore this box plot interactively →