DSG4

Across TCGA patient cohorts, DSG4 protein abundance is significantly associated with the RNA expression of many other genes, with 364 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible DSG4-associated genes across cancer lineages are VGLL1, CCL22, and MDM1. Each is linked with DSG4 in more than 1 cancer types. Because this analysis shows association rather than direction, both DSG4-to-partner and partner-to-DSG4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DSG4 versus VGLL1 in UCEC, with a Pearson correlation of 0.59.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSG4→partner) and Y-score (partner→DSG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VGLL1 →	+2.139	+1.760	.008	<.001	3	1
UCEC	CCL22 →	+1.581	+2.706	<.001	.003	3	1
UCEC	MDM1 →	-0.842	-2.601	<.001	.005	3	1
UCEC	ITGB6 →	+2.510	+3.808	.004	.009	3	1
UCEC	HMGN3 →	-0.780	-2.601	.004	.005	3	1
UCEC	ARHGAP40 →	+1.851	+4.053	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 364 associations by consensus.

DSG4 vs VGLL1 — UCEC

Explore this scatter interactively →