DSG4

Across TCGA patient cohorts, DSG4 mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DSG4-associated genes across cancer lineages are Cyclin-B1, Stathmin, and c-Kit. Each is linked with DSG4 in more than 2 cancer types. Because this analysis shows association rather than direction, both DSG4-to-partner and partner-to-DSG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by DSG4-low versus DSG4-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSG4→partner) and Y-score (partner→DSG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	Cyclin-B1 →	+0.590	+3.169	.001	.018	3	3
SKCM	Stathmin →	+0.112	+1.320	.011	.004	3	3
SKCM	c-Kit →	-0.502	-1.321	.001	<.001	3	3
COAD	TFRC →	+0.650	+3.025	.018	.019	3	3
COAD	ASNS →	+0.529	+3.008	.009	.019	3	3
UCEC	EGFR_pY1068 →	-0.204	-1.440	.005	.022	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

Cyclin-B1 by DSG4 expression — LUAD

Explore this box plot interactively →