DSG4

Across TCGA cell cohorts, DSG4 RNA expression is significantly associated with the go_rna of many other GO terms, with 469 significant associations in total. STOMACH shows the largest number of these associations.

The most reproducible DSG4-associated GO terms across cancer lineages are Response to flavonoid, Regulation of G protein-coupled receptor signaling pathway, and Intestinal lipid absorption. Each is linked with DSG4 in more than 3 cancer types. Because this analysis shows association rather than direction, both DSG4-to-partner and partner-to-DSG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to flavonoid grouped by DSG4-low versus DSG4-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DSG4→partner) and Y-score (partner→DSG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Response to flavonoid →	+0.090	+0.147	.009	.001	3	4
STOMACH	Regulation of G protein-coupled receptor signaling pathway →	-0.042	-0.151	.004	.001	3	4
LUNG_NSCLC_LUSC	Intestinal lipid absorption →	-0.312	-0.208	<.001	.008	3	3
LARGE_INTESTINE	CD27 signaling pathway →	-0.252	-0.547	<.001	.001	3	3
LARGE_INTESTINE	Negative regulation of metallopeptidase activity →	-0.373	-0.678	<.001	<.001	3	3
STOMACH	His-Purkinje system development →	+0.341	+0.136	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 469 associations by consensus.

Response to flavonoid by DSG4 expression — STOMACH

Explore this box plot interactively →