DSG4

Across TCGA cell cohorts, DSG4 mutation is significantly associated with the RNA expression of many other genes, with 34 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DSG4-associated genes across cancer lineages are C1QC, STH, and CST9L. Each is linked with DSG4 in more than 1 cancer types. Because this analysis shows association rather than direction, both DSG4-to-partner and partner-to-DSG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1QC grouped by DSG4-low versus DSG4-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSG4→partner) and Y-score (partner→DSG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	C1QC →	+0.026	+3.584	<.001	.003	3	2
BLOOD_Myeloma	STH →	+0.187	+3.906	<.001	.009	3	1
LUNG_NSCLC_LUAD	CST9L →	+0.035	+4.947	<.001	.001	3	1
LUNG_NSCLC_LUAD	SKOR2 →	+0.016	+4.947	<.001	.001	3	1
LUNG_NSCLC_LUAD	OR5M10 →	+0.014	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	LY6L →	+0.037	+5.266	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

C1QC by DSG4 expression — LUNG_SCLC

Explore this box plot interactively →