DSG3

Across TCGA patient cohorts, DSG3 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,831 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DSG3-associated proteins across cancer lineages are SERPINB5, KRT17, and FSCN1. Each is linked with DSG3 in more than 5 cancer types. Because this analysis shows association rather than direction, both DSG3-to-partner and partner-to-DSG3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DSG3 versus SERPINB5 in HNSC, with a Pearson correlation of 0.35.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DSG3→partner) and Y-score (partner→DSG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SERPINB5 →	+1.519	+1.629	<.001	<.001	3	6
COAD	KRT17 →	+1.590	+2.309	<.001	<.001	3	6
BRCA	FSCN1 →	+0.568	+1.627	<.001	<.001	3	5
PDAC	TRIM29_S21 →	+1.367	+1.366	<.001	<.001	3	5
PDAC	TRIM29_S489 →	+1.225	+1.907	.001	<.001	3	5
LSCC	VSNL1 →	+1.226	+2.466	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,831 associations by consensus.

DSG3 vs SERPINB5 — HNSC

Explore this scatter interactively →