DSG3

Across TCGA patient cohorts, DSG3 protein abundance is significantly associated with the RNA expression of many other genes, with 19,206 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible DSG3-associated genes across cancer lineages are KRT16, KLF5, and DLX5. Each is linked with DSG3 in more than 4 cancer types. Because this analysis shows association rather than direction, both DSG3-to-partner and partner-to-DSG3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DSG3 versus KRT16 in LSCC, with a Pearson correlation of 0.80.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSG3→partner) and Y-score (partner→DSG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	KRT16 →	+3.302	+1.681	<.001	<.001	3	5
BRCA	KLF5 →	+1.454	+1.183	<.001	<.001	3	4
UCEC	DLX5 →	+1.513	+1.205	.004	.007	3	4
BRCA	PREX1 →	-0.860	-0.760	.002	<.001	3	4
UCEC	DSC2 →	+2.621	+1.887	<.001	.002	3	4
LSCC	SPRR2D →	+3.510	+1.583	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,206 associations by consensus.

DSG3 vs KRT16 — LSCC

Explore this scatter interactively →