DSG3

Across TCGA patient cohorts, DSG3 mutation is significantly associated with the RNA expression of many other genes, with 6,336 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DSG3-associated genes across cancer lineages are LETM1, LRRC59, and HROB. Each is linked with DSG3 in more than 4 cancer types. Because this analysis shows association rather than direction, both DSG3-to-partner and partner-to-DSG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LETM1 grouped by DSG3-low versus DSG3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSG3→partner) and Y-score (partner→DSG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LETM1 →	+0.466	+2.652	.001	.005	3	5
UCEC	LRRC59 →	+0.566	+1.836	<.001	<.001	3	4
UCEC	HROB →	+0.450	+1.530	<.001	<.001	3	4
UCEC	CENPO →	+0.462	+2.212	<.001	<.001	3	4
UCEC	RITA1 →	+0.332	+2.202	<.001	<.001	3	4
SKCM	ACP1 →	+0.220	+0.957	.006	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,336 associations by consensus.

LETM1 by DSG3 expression — COAD

Explore this box plot interactively →