DSG3

Across TCGA cell cohorts, DSG3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,005 significant associations in total. OESOPHAGUS shows the largest number of these associations.

The most reproducible DSG3-associated GO terms across cancer lineages are Bundle of His cell to Purkinje myocyte communication, Regulation of ventricular cardiac muscle cell action potential, and Response to indole-3-methanol. Each is linked with DSG3 in more than 6 cancer types. Because this analysis shows association rather than direction, both DSG3-to-partner and partner-to-DSG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bundle of His cell to Purkinje myocyte communication grouped by DSG3-low versus DSG3-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DSG3→partner) and Y-score (partner→DSG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Bundle of His cell to Purkinje myocyte communication →	+0.242	+2.975	.005	.003	3	7
PANCREAS	Regulation of ventricular cardiac muscle cell action potential →	+0.166	+1.509	<.001	<.001	3	7
STOMACH	Response to indole-3-methanol →	+0.217	+3.044	.001	<.001	3	7
PANCREAS	Regulation of heart rate by cardiac conduction →	+0.196	+2.151	<.001	<.001	3	7
URINARY_TRACT	Desmosome organization →	+0.243	+2.575	.008	.003	3	7
URINARY_TRACT	Regulation of hair cycle →	+0.153	+3.732	.009	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,005 associations by consensus.

Bundle of His cell to Purkinje myocyte communication by DSG3 expression — URINARY_TRACT

Explore this box plot interactively →