DSG3

Across TCGA cell cohorts, DSG3 mutation is significantly associated with the RNA expression of many other genes, with 34 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible DSG3-associated genes across cancer lineages are OR4F5, PRSS38, and NPVF. Each is linked with DSG3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DSG3-to-partner and partner-to-DSG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4F5 grouped by DSG3-low versus DSG3-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSG3→partner) and Y-score (partner→DSG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR4F5 →	+0.012	+4.887	<.001	.009	3	2
UPPER_AERODIGESTIVE_TRACT	PRSS38 →	+0.025	+4.209	<.001	.006	3	2
LUNG_NSCLC_LUSC	NPVF →	+0.029	+4.108	.002	.005	3	1
SKIN	H1-1 →	+0.216	+3.694	.003	.003	3	1
SKIN	SLC10A2 →	+0.002	+3.700	<.001	.009	3	1
LUNG_NSCLC_LUAD	SPINT4 →	+0.047	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

OR4F5 by DSG3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →