DSG2

Across TCGA patient cohorts, DSG2 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,760 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DSG2-associated proteins across cancer lineages are DSC2, RFTN1, and RNMT. Each is linked with DSG2 in more than 6 cancer types. Because this analysis shows association rather than direction, both DSG2-to-partner and partner-to-DSG2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DSG2 versus DSC2 in LSCC, with a Pearson correlation of 0.41.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DSG2→partner) and Y-score (partner→DSG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DSC2 →	+0.616	+0.609	<.001	<.001	3	7
UCEC	RFTN1 →	-0.514	-0.506	<.001	.003	3	5
LSCC	RNMT →	+0.277	+0.544	<.001	.001	3	5
LSCC	TIMELESS_S1173 →	+0.636	+0.906	.001	<.001	3	5
UCEC	CD74 →	-0.546	-0.571	.001	<.001	3	5
UCEC	CDC73 →	+0.259	+0.575	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,760 associations by consensus.

DSG2 vs DSC2 — LSCC

Explore this scatter interactively →