DSG2

Across TCGA patient cohorts, DSG2 protein abundance is significantly associated with the protein abundance of many other proteins, with 22,175 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DSG2-associated proteins across cancer lineages are DSG2_S680, DSG2_S703, and ARHGEF6. Each is linked with DSG2 in more than 9 cancer types. Because this analysis shows association rather than direction, both DSG2-to-partner and partner-to-DSG2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DSG2 versus DSG2_S680 in LSCC, with a Pearson correlation of 0.74.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DSG2→partner) and Y-score (partner→DSG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DSG2_S680 →	+1.250	+0.619	<.001	<.001	3	10
LUAD	DSG2_S703 →	+1.429	+0.757	<.001	<.001	3	10
OV	ARHGEF6 →	-0.452	-0.549	<.001	<.001	3	9
OV	PKP2 →	+1.231	+0.707	<.001	<.001	3	9
HNSC	EPCAM →	+0.851	+0.421	<.001	<.001	3	9
OV	ANKRD44 →	-0.474	-0.572	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 22,175 associations by consensus.

DSG2 vs DSG2_S680 — LSCC

Explore this scatter interactively →