DSG2

Across TCGA cell cohorts, DSG2 mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DSG2-associated genes across cancer lineages are OR10R2, DRD3, and PPDPFL. Each is linked with DSG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DSG2-to-partner and partner-to-DSG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10R2 grouped by DSG2-low versus DSG2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSG2→partner) and Y-score (partner→DSG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR10R2 →	+1.230	+3.288	<.001	<.001	3	2
OESOPHAGUS	DRD3 →	+0.036	+4.906	<.001	.006	3	1
OESOPHAGUS	PPDPFL →	+0.033	+4.906	<.001	.006	3	1
OESOPHAGUS	SCYGR10 →	+0.203	+4.906	<.001	.006	3	1
BLOOD_Leukemia	TCF21 →	+0.009	+2.799	<.001	.005	3	1
BLOOD_Leukemia	BHLHE23 →	+0.968	+2.761	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

OR10R2 by DSG2 expression — BLOOD_Leukemia

Explore this box plot interactively →