DSG1

Across TCGA patient cohorts, DSG1 protein abundance is significantly associated with the RNA expression of many other genes, with 10,502 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible DSG1-associated genes across cancer lineages are KRT17, DSC3, and PGLYRP3. Each is linked with DSG1 in more than 2 cancer types. Because this analysis shows association rather than direction, both DSG1-to-partner and partner-to-DSG1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DSG1 versus KRT17 in LSCC, with a Pearson correlation of 0.50.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSG1→partner) and Y-score (partner→DSG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	KRT17 →	+3.262	+0.997	<.001	<.001	3	3
BRCA	DSC3 →	+2.885	+1.457	.001	.002	3	3
LSCC	PGLYRP3 →	+2.041	+0.997	<.001	.001	3	3
LSCC	KRT16 →	+3.866	+0.992	<.001	.001	3	3
BRCA	SERPINB5 →	+2.903	+1.412	<.001	.004	3	3
LSCC	ATP5MC1P6 →	+1.888	+0.982	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,502 associations by consensus.

DSG1 vs KRT17 — LSCC

Explore this scatter interactively →