DSG1

Across TCGA patient cohorts, DSG1 mutation is significantly associated with the RNA expression of many other genes, with 4,140 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DSG1-associated genes across cancer lineages are DSCR4-IT1, RTN4IP1, and SNORA10B. Each is linked with DSG1 in more than 3 cancer types. Because this analysis shows association rather than direction, both DSG1-to-partner and partner-to-DSG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DSCR4-IT1 grouped by DSG1-low versus DSG1-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSG1→partner) and Y-score (partner→DSG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	DSCR4-IT1 →	+0.443	+5.039	<.001	.008	3	4
UCEC	RTN4IP1 →	+0.256	+1.430	.002	.002	3	4
UCEC	SNORA10B →	+0.111	+1.674	<.001	.004	3	4
BLCA	RPS10P21 →	+0.090	+2.773	.005	.008	3	3
LUAD	NUP88 →	+0.376	+3.608	.001	.001	3	3
LUAD	CD207 →	-1.524	-2.798	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,140 associations by consensus.

DSCR4-IT1 by DSG1 expression — READ

Explore this box plot interactively →