DSG1

Across TCGA patient cohorts, DSG1 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DSG1-associated genes across cancer lineages are 4E-BP1, ATM, and Cyclin-B1. Each is linked with DSG1 in more than 3 cancer types. Because this analysis shows association rather than direction, both DSG1-to-partner and partner-to-DSG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by DSG1-low versus DSG1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSG1→partner) and Y-score (partner→DSG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.220	+2.321	.003	.005	3	4
UCEC	ATM →	-0.406	-2.156	.001	.002	3	3
UCEC	Cyclin-B1 →	+0.615	+2.662	<.001	<.001	3	3
UCEC	eIF4E →	+0.156	+1.652	.007	.005	3	2
LUSC	SETD2 →	-0.208	-1.691	.047	.043	3	2
UCEC	ERK2 →	+0.157	+1.938	.003	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

4E-BP1 by DSG1 expression — UCEC

Explore this box plot interactively →