DSG1

Across TCGA cell cohorts, DSG1 RNA expression is significantly associated with the go_rna of many other GO terms, with 739 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DSG1-associated GO terms across cancer lineages are Negative regulation of organelle assembly, Ventricular cardiac muscle cell development, and Regulation of nuclear-transcribed mRNA poly(A) tail shortening. Each is linked with DSG1 in more than 3 cancer types. Because this analysis shows association rather than direction, both DSG1-to-partner and partner-to-DSG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of organelle assembly grouped by DSG1-low versus DSG1-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DSG1→partner) and Y-score (partner→DSG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Negative regulation of organelle assembly →	+0.046	+0.432	.001	.009	3	4
LIVER	Ventricular cardiac muscle cell development →	-0.335	-0.100	<.001	.006	3	4
SKIN	Regulation of nuclear-transcribed mRNA poly(A) tail shortening →	+0.052	+0.042	.001	.001	3	4
BLOOD_Leukemia	Regionalization →	-0.025	-0.064	<.001	.006	3	4
BLOOD_Leukemia	Potassium ion transport →	-0.020	-0.054	.003	.002	3	4
BLOOD_Leukemia	Pattern specification process →	-0.027	-0.068	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 739 associations by consensus.

Negative regulation of organelle assembly by DSG1 expression — BLOOD_Myeloma

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