DSG1

Across TCGA cell cohorts, DSG1 mutation is significantly associated with the RNA expression of many other genes, with 110 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DSG1-associated genes across cancer lineages are INHBC, GGTLC1, and KRTAP8-1. Each is linked with DSG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DSG1-to-partner and partner-to-DSG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INHBC grouped by DSG1-low versus DSG1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSG1→partner) and Y-score (partner→DSG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	INHBC →	+0.511	+3.351	.002	.003	3	2
BONE	GGTLC1 →	+0.049	+5.169	<.001	.004	3	1
BONE	KRTAP8-1 →	+0.053	+5.169	<.001	.004	3	1
BLOOD_Myeloma	RBP3 →	+0.006	+4.807	<.001	.006	3	1
LUNG_NSCLC_LUSC	KLRF2 →	+0.193	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUAD	OR1L6 →	+0.011	+4.078	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 110 associations by consensus.

INHBC by DSG1 expression — BLOOD_Leukemia

Explore this box plot interactively →