DSE

Across TCGA pan-cancer cohorts, DSE mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated DSE data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher DSE mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated DSE expression acts as an unfavorable survival marker.

PDAC, LUAD, and HNSC are the cancer types where DSE mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	All	0.335	0.643	<.001	72	view →
LUAD	DFS	Median	All	0.673	0.900	.009	16	view →
HNSC	DFS	Tertile	IV	0.420	0.889	.038	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

DSE–PDAC (OS)

Open the PDAC breakdown →