DSE

Across TCGA patient cohorts, DSE protein abundance is significantly associated with the RNA expression of many other genes, with 8,262 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DSE-associated genes across cancer lineages are TNFAIP6, LGALS1, and COL12A1. Each is linked with DSE in more than 3 cancer types. Because this analysis shows association rather than direction, both DSE-to-partner and partner-to-DSE results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DSE versus TNFAIP6 in LSCC, with a Pearson correlation of 0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSE→partner) and Y-score (partner→DSE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TNFAIP6 →	+1.221	+0.473	<.001	<.001	3	4
LSCC	LGALS1 →	+1.171	+0.458	<.001	<.001	3	3
LUAD	COL12A1 →	+1.460	+0.343	<.001	.006	3	3
LSCC	TSHZ3 →	+0.740	+0.374	.001	.006	3	3
LSCC	MICAL2 →	+1.088	+0.590	<.001	<.001	3	3
LSCC	ADAMTS12 →	+1.077	+0.422	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,262 associations by consensus.

DSE vs TNFAIP6 — LSCC

Explore this scatter interactively →