DSE

Across TCGA patient cohorts, DSE mutation is significantly associated with the RNA expression of many other genes, with 2,411 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DSE-associated genes across cancer lineages are COX6B1P2, DBIP2, and MND1. Each is linked with DSE in more than 2 cancer types. Because this analysis shows association rather than direction, both DSE-to-partner and partner-to-DSE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COX6B1P2 grouped by DSE-low versus DSE-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSE→partner) and Y-score (partner→DSE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	COX6B1P2 →	+0.257	+5.625	<.001	.004	3	3
BLCA	DBIP2 →	+0.823	+4.343	<.001	.002	3	3
UCEC	MND1 →	+0.567	+1.546	.001	.008	3	3
UCEC	TEDC2 →	+0.552	+2.502	<.001	.001	3	3
LIHC	RNA5SP531 →	+0.201	+5.584	<.001	.001	3	2
LIHC	LINC02464 →	+0.163	+4.693	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,411 associations by consensus.

COX6B1P2 by DSE expression — LUSC

Explore this box plot interactively →