DSE

Across TCGA patient cohorts, DSE mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DSE-associated genes across cancer lineages are Cyclin-E2, Acetyl-a-Tubulin-Lys40, and Caspase-8. Each is linked with DSE in more than 2 cancer types. Because this analysis shows association rather than direction, both DSE-to-partner and partner-to-DSE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by DSE-low versus DSE-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSE→partner) and Y-score (partner→DSE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	Cyclin-E2 →	+0.265	+2.817	.013	.037	3	3
SKCM	Acetyl-a-Tubulin-Lys40 →	+0.474	+1.906	.012	.014	3	2
UCEC	Caspase-8 →	-0.211	-2.295	.006	<.001	3	2
UCEC	P-Cadherin →	-0.104	-1.999	.018	.008	3	2
UCEC	PCNA →	+0.200	+1.440	.002	.022	3	2
UCEC	Rictor_pT1135 →	-0.084	-1.700	.007	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Cyclin-E2 by DSE expression — BRCA

Explore this box plot interactively →