DSCC1

Across TCGA pan-cancer cohorts, DSCC1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated DSCC1 data layer compared with 31 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher DSCC1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DSCC1 expression acts as an unfavorable survival marker, although some lineages such as GBM and LSCC show a favorable association.

GBM, LSCC, and HNSC are the cancer types where DSCC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Tertile	All	0.813	0.424	.005	15	view →
LSCC	OS	Quartile	II,III,IV	1.000	0.655	.012	12	view →
HNSC	OS	Median	All	0.777	0.910	.003	8	view →
LUAD	DFS	Median	III,IV	0.867	0.683	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

DSCC1–GBM (DFS)

Open the GBM breakdown →