DSCC1

Across TCGA patient cohorts, DSCC1 mutation is significantly associated with the RNA expression of many other genes, with 719 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DSCC1-associated genes across cancer lineages are PPIAP5, DHRS11, and GPR32. Each is linked with DSCC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DSCC1-to-partner and partner-to-DSCC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPIAP5 grouped by DSCC1-low versus DSCC1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSCC1→partner) and Y-score (partner→DSCC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PPIAP5 →	+0.140	+4.813	.001	.003	3	2
UCEC	DHRS11 →	+0.550	+2.711	.003	.003	3	1
COAD	GPR32 →	+0.077	+5.145	<.001	.007	3	1
UCEC	ESS2 →	+0.399	+3.818	<.001	<.001	3	1
UCEC	GGA1 →	+0.354	+3.828	.008	<.001	3	1
UCEC	CENPM →	+0.855	+3.807	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 719 associations by consensus.

PPIAP5 by DSCC1 expression — HNSC

Explore this box plot interactively →