DSCC1

Across TCGA patient cohorts, DSCC1 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DSCC1-associated genes across cancer lineages are ACVRL1, Ku80, and MEK1. Each is linked with DSCC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DSCC1-to-partner and partner-to-DSCC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACVRL1 grouped by DSCC1-low versus DSCC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSCC1→partner) and Y-score (partner→DSCC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACVRL1 →	-0.210	-3.321	.003	.010	3	1
UCEC	Ku80 →	+0.246	+2.183	.046	.035	3	1
UCEC	MEK1 →	+0.402	+3.321	.036	.010	3	1
UCEC	mTOR_pS2448 →	-0.209	-3.150	.007	.019	3	1
UCEC	Myosin-IIa_pS1943 →	+0.265	+2.183	.014	.035	3	1
UCEC	Myosin-IIa →	+0.205	+2.177	.034	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

ACVRL1 by DSCC1 expression — UCEC

Explore this box plot interactively →