DSCC1

Across TCGA cell cohorts, DSCC1 mutation is significantly associated with the mutation status of many other genes, with 1,529 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DSCC1-associated genes across cancer lineages are DIPK2B, MAGEA4, and TIMM8B. Each is linked with DSCC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DSCC1-to-partner and partner-to-DSCC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DIPK2B grouped by DSCC1-low versus DSCC1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSCC1→partner) and Y-score (partner→DSCC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DIPK2B →	+5.087	+4.523	.006	.006	1	2
LARGE_INTESTINE	MAGEA4 →	+5.672	+5.672	<.001	<.001	1	2
LARGE_INTESTINE	TIMM8B →	+5.087	+4.523	.006	.006	1	2
LARGE_INTESTINE	ZSCAN1 →	+3.087	+4.392	.005	.005	1	2
LARGE_INTESTINE	CDC20B →	+3.350	+4.584	.003	.003	1	2
LARGE_INTESTINE	NUDT21 →	+5.087	+4.523	.006	.006	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,529 associations by consensus.

DIPK2B by DSCC1 expression — LARGE_INTESTINE

Explore this box plot interactively →