DSCAML1

Across TCGA pan-cancer cohorts, DSCAML1 Mutation is linked to patient survival in 14 of 34 cancer types, making it a survival-associated DSCAML1 data layer compared with 25 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher DSCAML1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated DSCAML1 expression acts as an unfavorable survival marker, although some lineages such as STAD and UCEC show a favorable association.

KIRP, KIRC, and STAD are the cancer types where DSCAML1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.040	0.896	<.001	36	view →
KIRC	DFS	Median	All	0.123	0.796	<.001	24	view →
STAD	DFS	Median	II,III,IV	0.773	0.353	.017	20	view →
LAML	DFS	Median	All	0.028	0.572	<.001	12	view →
DLBC	DFS	Median	II,III,IV	0.022	0.837	<.001	12	view →
UCEC	DFS	Median	All	0.759	0.627	.010	12	view →
OV	DFS	Median	IV	0.118	0.470	.004	6	view →
LUAD	OS	Median	III,IV	0.211	0.667	.017	6	view →
HNSC	OS	Median	III,IV	0.402	0.631	.048	6	view →
PRAD	DFS	Median	All	0.629	0.887	.032	4	view →
LUSC	OS	Median	III,IV	0.416	0.680	.043	3	view →
SCLC	DFS	Median	II,III,IV	0.301	0.621	.039	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

DSCAML1–KIRP (DFS)

Open the KIRP breakdown →