DSCAML1

Across TCGA patient cohorts, DSCAML1 mutation is significantly associated with the total protein of many other genes, with 115 significant associations in total. COAD shows the largest number of these associations.

The most reproducible DSCAML1-associated genes across cancer lineages are PCNA, 14-3-3_epsilon, and NF-kB-p65_pS536. Each is linked with DSCAML1 in more than 4 cancer types. Because this analysis shows association rather than direction, both DSCAML1-to-partner and partner-to-DSCAML1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by DSCAML1-low versus DSCAML1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSCAML1→partner) and Y-score (partner→DSCAML1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	PCNA →	+0.273	+2.807	.002	.002	3	5
COAD	14-3-3_epsilon →	+0.120	+1.717	<.001	.022	3	4
COAD	NF-kB-p65_pS536 →	-0.396	-1.502	.005	.023	3	4
SKCM	LKB1 →	+0.092	+1.514	.003	.010	3	4
COAD	CD49b →	+0.290	+2.330	<.001	<.001	3	4
LUAD	SCD →	+0.091	+2.016	.033	.015	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 115 associations by consensus.

PCNA by DSCAML1 expression — STAD

Explore this box plot interactively →