DSCAML1

Across TCGA cell cohorts, DSCAML1 mutation is significantly associated with the RNA expression of many other genes, with 1,175 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DSCAML1-associated genes across cancer lineages are GRSF1, ISCA1, and BBS7. Each is linked with DSCAML1 in more than 2 cancer types. Because this analysis shows association rather than direction, both DSCAML1-to-partner and partner-to-DSCAML1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GRSF1 grouped by DSCAML1-low versus DSCAML1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSCAML1→partner) and Y-score (partner→DSCAML1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GRSF1 →	+0.522	+1.889	<.001	<.001	3	3
LARGE_INTESTINE	ISCA1 →	+0.379	+3.409	.001	<.001	3	3
LARGE_INTESTINE	BBS7 →	+0.679	+1.891	<.001	<.001	3	3
LARGE_INTESTINE	KLHL8 →	+0.493	+2.115	.003	.004	3	3
LARGE_INTESTINE	BRWD1 →	+0.575	+2.115	<.001	.004	3	3
LARGE_INTESTINE	ELOA3CP →	+0.068	+1.294	.006	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,175 associations by consensus.

GRSF1 by DSCAML1 expression — LARGE_INTESTINE

Explore this box plot interactively →