DSCAM

Across TCGA pan-cancer cohorts, DSCAM Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated DSCAM data layer compared with 23 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher DSCAM Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DSCAM expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

THYM, KIRC, and THCA are the cancer types where DSCAM Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
KIRC	OS	Median	All	0.054	0.881	<.001	42	view →
THCA	OS	Median	All	0.178	0.952	<.001	21	view →
UCEC	DFS	Median	All	0.891	0.603	.001	14	view →
CESC	OS	Median	III,IV	0.068	0.756	<.001	12	view →
ACC	OS	Median	All	0.152	0.632	.008	12	view →
SKCM	OS	Median	II,III,IV	0.921	0.800	.004	11	view →
DLBC	OS	Median	II,III,IV	0.118	0.802	.025	6	view →
HNSC	OS	Median	II,III,IV	0.209	0.716	.001	6	view →
COAD	OS	Median	All	0.279	0.714	.009	5	view →
OV	DFS	Median	All	0.937	0.533	.019	4	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

DSCAM–THYM (OS)

Open the THYM breakdown →