DSCAM-IT1

Across TCGA pan-cancer cohorts, DSCAM-IT1 RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated DSCAM-IT1 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher DSCAM-IT1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DSCAM-IT1 expression acts as an unfavorable survival marker, although some lineages such as LGG and STAD show a favorable association.

ACC, KICH, and CHOL are the cancer types where DSCAM-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Tertile	All	0.199	0.818	<.001	189	view →
KICH	DFS	Tertile	All	0.312	0.913	<.001	108	view →
CHOL	DFS	Tertile	All	0.045	0.486	.009	45	view →
LGG	OS	Median	All	0.533	0.376	<.001	43	view →
STAD	OS	Tertile	IV	0.774	0.200	.002	38	view →
BRCA	DFS	Tertile	IV	0.175	0.730	.005	36	view →
ESCA	DFS	Tertile	IV	0.826	0.284	.034	36	view →
DLBC	OS	Tertile	III,IV	0.154	0.735	.010	28	view →
LUSC	DFS	Tertile	II,III,IV	0.199	0.748	.033	9	view →
THCA	DFS	Tertile	IV	0.146	0.844	.007	9	view →
HNSC	OS	Tertile	IV	0.518	0.691	.043	2	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

DSCAM-IT1–ACC (OS)

Open the ACC breakdown →