DSC3

Across TCGA pan-cancer cohorts, DSC3 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated DSC3 data layer compared with 23 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher DSC3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated DSC3 expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

PDAC, UCEC, and LSCC are the cancer types where DSC3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	All	0.478	0.289	.027	5	view →
UCEC	DFS	Median	All	1.000	0.853	.032	2	view →
LSCC	DFS	Median	II,III,IV	0.963	0.867	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

DSC3–PDAC (OS)

Open the PDAC breakdown →