DSC3

Across TCGA patient cohorts, DSC3 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,601 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DSC3-associated proteins across cancer lineages are BICD2_S823, FRMD6, and HID1. Each is linked with DSC3 in more than 4 cancer types. Because this analysis shows association rather than direction, both DSC3-to-partner and partner-to-DSC3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DSC3 versus BICD2_S823 in LSCC, with a Pearson correlation of 0.68.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DSC3→partner) and Y-score (partner→DSC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	BICD2_S823 →	+1.305	+2.462	<.001	<.001	3	5
UCEC	FRMD6 →	+0.584	+1.085	<.001	<.001	3	5
BRCA	HID1 →	-0.588	-2.059	<.001	<.001	3	5
BRCA	KRT14 →	+1.809	+1.866	<.001	.001	3	5
LSCC	KRT5_S50 →	+1.432	+2.005	<.001	<.001	3	5
PDAC	KRT5_S75 →	+2.304	+1.766	.003	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,601 associations by consensus.

DSC3 vs BICD2_S823 — LSCC

Explore this scatter interactively →