DSC3

Across TCGA patient cohorts, DSC3 protein abundance is significantly associated with the RNA expression of many other genes, with 16,339 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DSC3-associated genes across cancer lineages are IFFO2, HMGB3P8, and KRT17. Each is linked with DSC3 in more than 3 cancer types. Because this analysis shows association rather than direction, both DSC3-to-partner and partner-to-DSC3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DSC3 versus IFFO2 in HNSC, with a Pearson correlation of 0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSC3→partner) and Y-score (partner→DSC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	IFFO2 →	+0.817	+0.597	<.001	<.001	3	4
HNSC	HMGB3P8 →	+1.273	+0.575	.001	<.001	3	4
BRCA	KRT17 →	+2.263	+0.889	<.001	<.001	3	4
BRCA	FOSL1 →	+1.033	+0.815	<.001	<.001	3	4
HNSC	FAM89A →	+0.785	+0.694	<.001	<.001	3	4
LSCC	KRT14 →	+2.999	+1.207	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,339 associations by consensus.

DSC3 vs IFFO2 — HNSC

Explore this scatter interactively →