DSC3

Across TCGA patient cohorts, DSC3 mutation is significantly associated with the RNA expression of many other genes, with 5,286 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DSC3-associated genes across cancer lineages are AATF, BUB3, and SKA1. Each is linked with DSC3 in more than 3 cancer types. Because this analysis shows association rather than direction, both DSC3-to-partner and partner-to-DSC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AATF grouped by DSC3-low versus DSC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSC3→partner) and Y-score (partner→DSC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AATF →	+0.332	+1.784	.001	<.001	3	3
UCEC	BUB3 →	+0.459	+2.212	<.001	<.001	3	3
UCEC	SKA1 →	+0.647	+2.513	<.001	<.001	3	3
UCEC	EME1 →	+0.413	+1.595	.003	<.001	3	3
UCEC	SUPV3L1 →	+0.336	+2.010	<.001	<.001	3	3
UCEC	ENTR1 →	+0.368	+1.627	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,286 associations by consensus.

AATF by DSC3 expression — UCEC

Explore this box plot interactively →