DSC2

Across TCGA pan-cancer cohorts, DSC2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DSC2 data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DSC2 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated DSC2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, PDAC, and LSCC are the cancer types where DSC2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	1.000	0.350	.022	27	view →
PDAC	OS	Median	IV	0.381	0.951	.006	18	view →
LSCC	DFS	Tertile	III,IV	0.958	0.437	.008	11	view →
LUAD	DFS	Quartile	II,III,IV	0.208	0.866	.013	3	view →
CCRCC	OS	Median	III,IV	1.000	0.831	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DSC2–HNSC (OS)

Open the HNSC breakdown →